Asik SyedA game-changing development in Nanoparticle Cancer Therapy methods has emerged with the creation of a simplified, one-step method to synthesize nanoparticles tailored for photothermal treatment (PTT). This technique introduces a novel nanostructure with promising medical applications.
Colloidal Synthesis for Nanoparticle Cancer Therapy Method
Unlike conventional methods that rely on complex, multi-step processes and harsh chemicals, the new synthesis produces semi-shell (SS) nanoparticles shaped like tiny cups. These are formed at room temperature using a biocompatible metal-organic framework—ZIF-8—as a sacrificial mold, making the entire process safer and more sustainable.
Cleaner, Safer, and More Accessible
The innovation sidesteps toxic reagents and high heat, using mild reducing agents like ascorbic acid (Vitamin C). The process is notably straightforward and doesn’t require expensive or specialized lab equipment—broadening its use in both laboratory and clinical settings.
Exceptional Optical Features for Cancer Targeting
These semi-shell nanoparticles demonstrate strong light absorption and scattering in the near-infrared range—crucial for the effectiveness of photothermal therapy. Their unique optical traits were rigorously tested to ensure medical reliability and performance.
Effective Cancer Destruction with Minimal Side Effects
Lab and animal studies confirmed that PEGylated semi-shells offer high photothermal conversion efficiency and are biocompatible. In tests on metastatic breast cancer, these particles enabled successful tumour ablation, significantly boosting survival outcomes in experimental models.
Expanding the Horizons of Cancer Nanomedicine
Future research will aim to merge this photothermal strategy with chemotherapy for a more targeted approach. Additionally, the particles’ optical capabilities could be tapped for advanced biosensing techniques like Surface-Enhanced Raman Spectroscopy (SERS), hinting at broader diagnostic and therapeutic uses.
Neha Baruah
Tazrin Jakaria
Pinki Borah